Hydroxyzine and melatonin are two medications that are commonly used by people for various reasons. Hydroxyzine is an antihistamine medication that can be used to treat anxiety, allergies, and other conditions. On the other hand, melatonin is a hormonal supplement that can help regulate sleep-wake cycles. Many people wonder if it is safe to take both hydroxyzine and melatonin together, or how long they need to wait after taking one before taking the other. In this article, we will explore the details of these medications and answer the question “how long after taking hydroxyzine can I take melatonin?”


Hydroxyzine belongs to a class of drugs called antihistamines. It works by blocking histamine receptors in the body which helps reduce allergic reactions such as inflammation, itching and skin rashes.

Apart from treating allergies symptoms like hives or itchiness, hydroxyzine also has sedative effects which makes it useful for treating anxiety disorders because of its calming effect.

However, you should only use hydroxyzine under medical supervision because at higher doses it may cause potential side effects or physical dependency.


Melatonin is a hormone produced naturally by your brain’s pineal gland in response to darkness or low light levels indicating time for sleep onset.

It regulates sleep-wake cycles so when administered properly as a supplement it acts as an aid in promoting healthy overall sleeping patterns especially during jet lag situations with altered day-night ratios.

Interactions between Hydroxyzine And Melatonin

Interactions between Hydroxyzine And Melatonin

When taken together there does not appear to pose any significant health risks related to drug interactions since neither directly interacts affecting one another mechanism.

However due to different metabolic rates differences caution should be taken especially limiting using high dosages of each medication within close timing thus avoiding unwanted side-effects happening simultaneously requiring immediate medical attention.

How Long After Taking Hydroxyzine Can You Take Melatonin?

There is no clear-cut answer to this question, since the timing of medication depends on many factors such as medical history and dosage strength.

In general, you should wait for at least two hours after taking hydroxyzine before taking melatonin to avoid any possible interactions. This also helps in determining if there are any side effects from the first medication so that the new one can be assessed accordingly.

For more detailed information related to recommended doses or change of these medications it is highly advisable to consult your primary healthcare professional who knows best about how they may work specifically with your personal medical condition and needs.


Hydroxyzine and Melatonin are both relatively safe medications when taken properly in moderation under proper physician guidance.

Taking both medications daily however requires working together with a medical advisor or carefully coordinating prescription advice between specialists due its potential risks within affecting specific metabolic process or producing conditionally-based adverse reactions. It’s therefore important to only follow prescriptions closely and not self-medicate without proper clinical supervision especially when using other drugs concurrently as complications can arise requiring emergency care intervention.
In summary, hydroxyzine and melatonin are two medications that can be used for various reasons but should only be taken under medical supervision. Hydroxyzine is an antihistamine that can treat allergies and anxiety, while melatonin is a hormone supplement that regulates sleep-wake cycles.

When taken together, there doesn’t appear to be any substantial health risks related to drug interactions. However, caution must always be taken given individual differences in metabolic rates so as to avoid side effects caused by high dosages of medication or over-lapping intake time periods.

To reduce the risk of adverse reactions, it’s best wait for at least two hours after taking hydroxyzine before using melatonin. If you’re considering taking either or both medications simultaneously it’s highly recommended to consult with your primary healthcare professional who knows what works specifically with your personal medical conditions or needs.

Overall- whilst combining different types of drugs may seem ideal for providing relief from multiple symptoms in one go-it is important always err on the side of caution and only take such combinations under proper clinical supervision-especially when those have addictive potentials which require gradual weaning off process (like most anti-anxiety adjuncts-hydroxyzine).